H2 Therapeutics: reviews

Scientific Support

Hydrogen therapy is an emerging therapeutic strategy to target and eliminate free radicals. Removing free radicals has demonstrated numerous health benefits, but does hydrogen therapy really work?

Below are peer-reviewed scientific articles that show the benefits in the following diseases

Parkinson's Disease

Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson's disease
https://www.ncbi.nlm.nih.gov/pubmed/30713666

Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.
https://www.ncbi.nlm.nih.gov/pubmed/19356598

Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
https://www.ncbi.nlm.nih.gov/pubmed/19789628

Pilot study of H₂ therapy in Parkinson's disease: a randomized double-blind placebo-controlled trial.
https://www.ncbi.nlm.nih.gov/pubmed/23400965

Cancer

Hydrogen gas inhibits lung cancer progression through targeting SMC3
https://www.ncbi.nlm.nih.gov/pubmed/29852353

Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation.
https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1241-x

Rheumatoid Arthritis

Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress
https://www.ncbi.nlm.nih.gov/pubmed/27830032

Stroke-Induced Brain Injury

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
https://www.ncbi.nlm.nih.gov/pubmed/17486089

Stroke-Induced Liver Injury

Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.
https://www.ncbi.nlm.nih.gov/pubmed/17673169

Metabolic Syndrome (diabetes, high cholesterol, obesity, high blood pressure)

Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome—An Open Label Pilot Study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831093/

Sepsis (bacterial infection)

Protective effects of hydrogen gas on murine polymicrobial sepsis via reducing oxidative stress and HMGB1 release.
https://www.ncbi.nlm.nih.gov/pubmed/19997046

Hydrogen Gas Alleviates the Intestinal Injury Caused by Severe Sepsis in Mice by Increasing the Expression of Heme Oxygenase-1
https://www.ncbi.nlm.nih.gov/pubmed/25895145

Heart Attack

The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction　- First Pilot Study in Humans.
https://www.ncbi.nlm.nih.gov/pubmed/28321000

Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
https://www.ncbi.nlm.nih.gov/pubmed/25366995

Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome　- First-in-Human Pilot Study.
https://www.ncbi.nlm.nih.gov/pubmed/27334126

Kidney Injury

Inhalation of Hydrogen Gas Is Beneficial for Preventing Contrast-Induced Acute Kidney Injury in Rats.
https://www.ncbi.nlm.nih.gov/pubmed/25592271

Hydrogen gas alleviates chronic intermittent hypoxia-induced renal injury through reducing iron overload.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471060/

Hemorrhagic Shock

Hydrogen gas inhalation inhibits progression to the "irreversible" stage of shock after severe hemorrhage in rats.
https://www.ncbi.nlm.nih.gov/pubmed/28640781

Execise Recovery

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes.
https://www.ncbi.nlm.nih.gov/pubmed/22520831

Hydrogen water drinking exerts antifatigue effects in chronic forced swimming mice via antioxidative and anti-inflammatory activities.
https://www.ncbi.nlm.nih.gov/pubmed/29850492

Eye Disease

The role of the reactive oxygen species and oxidative stress in the pathomechanism of the age-related ocular diseases and other pathologies of the anterior and posterior eye segments in adults.
https://www.ncbi.nlm.nih.gov/pubmed/26881021

Asthma

Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice.
https://www.ncbi.nlm.nih.gov/pubmed/29568538